McGillis married three men and divorced them all; her spouses are Melanie Leis (m. 2010–2011), Fred Tillman (m. 1989–2002), and Boyd Black (m. 1979–1981).
Kelsey, 19, and Sonora, 16, are her children from her second marriage to California millionaire Fred Tillian, which lasted 13 years.
When McGillis and Leis shared a home in Collingswood, she worked full-time with drug users and alcoholics at Seabrook House Drug Alcohol Rehab Center in Bridgeton, New Jersey.
McGillis now calls Hendersonville, North Carolina home. She has been teaching acting at the New York Studio for Stage and Screen NYS3 in Asheville, North Carolina since 2013.