While working for the ABC, she also did voice acting work, mainly voicing cartoon characters for the “ABC Weekend Special”; she is known to have voiced Scruffy in the animated film of the same name based on the book “Scruffy: The Tuesday Dog”. She was then hired by NBC for the sitcom adaptation of “Working Girl”, which starred the then unknown Sandra Bullock. In 1994, McKeon auditioned for the role of Monica Geller on “Friends”, but losing the role to Courtney Cox. When asked about the role, she mentioned that Cox was a good choice for the role, and she can’t imagine anyone else playing the character.
In 1995, she became the star of the series “Can’t Hurry Love” which was short lived, being cancelled after one season, and her next major project would come in 1998 in “Style & Substance”, starring alongside Jean Smart. In 2001, she played inspector Jinny Exstead in the Lifetime series “The Division”, a police procedural drama focused on female officers and detectives. Her real life pregnancy was written into the show during the last year of the series.