After completing his graduation, Lane used to work as a graduate assistant for Colorado State University. Following that, he became a quality control assistant of Jacksonville Jaguars. Later, Pete Carroll selected him as a tight end coach. During the 2001 season, he started working with the University of Southern California. He helped the University of Southern California to maintain a record of 23 – 3.
In 2007, Kiffin became the youngest head coach in the history of Oakland Raiders. Later, he went on to become the biggest burst in the history of the NFL. However, he left the Oakland Raiders and became the football coach of the University of Tennessee Volunteers. During his term, some fans and students were not happy with his functioning style, which made him depart from Tennessee.
Lane then returned to USC and became the head coach of Trojans. He had a successful out there and remained with the team till the 2013 season. Soon after leaving USC, he was hired by Alabama Crimson Tide football. In 2016, he became the head coaching position for Florida Atlantic University. He remained with the team for three seasons, and in 2019, he led FAU in winning C-USA Championship.
In December 2019, Lane accepted the position of head coach at Ole Miss Rebels. He was officially announced as the head coach of the team on December 9.
