Jordana Spiro is a New York native who grew up in the city. She was brought up in a Jewish household. Spiro has three sisters and a brother.

She attended the Circle in the Square Theatre School and the Royal Academy of Dramatic Art in London for a short time. She enrolled in Columbia University’s MFA Program in Filmmaking in the fall of 2009.

In 2015, she completed her degree. Spiro shares her time between Los Angeles and New York at the moment.

Catherine Reece in From Dusk Till Dawn 3: The Hangman’s Daughter, a direct-to-DVD prequel to the 1996 picture From Dusk Till Dawn, was Spiro’s first cinematic role.

Spiro featured in My Boys, a TBS original comedy sitcom. She also played P.J., a twenty-something “guy’s girl” in the film.