Wayans dated Angela Zackery from September 1992 to March 2013 and she is the mother of his two children: Amai Zackery Wayans (b. May 24, 2000), and Shawn Howell Wayans, (b. February 3, 2002).
Wayans is a fan of the Pittsburgh Steelers and the New York Knicks. Wayans was close friends with rapper Tupac Shakur until his death in 1996.. Wayans is also a longtime friend of actor Omar Epps.
