According to , Reiss Nelson receives an annual salary of £780,000 from the professional football club Arsenal.

The winger made his Premier League debut on 20 January 2018 in a 4-1 victory over Crystal Palace. He entered the game as a substitute in the 72nd minute.

He earned his first Premier League start in a 3-2 victory over Southampton on 8 April 2018, being substituted off for Jack Wilshere in the 64th minute. He was named the PL2 Player of the Year on 17 May 2018.

Arsenal ace Reiss made his U21 debut against Andorra on 11 October 2018, entering as a second-half substitute. He gained the 6th goal for the Young Lions with a backheel in stoppage time in a 7-0 win that ensured entrance for the 2019 UEFA European Under-21 Championship.

Nelson stated in 2018 that he was eligible to play for Zimbabwe and England, but his long-term goal was to represent England, calling it a dream come true.