On August 8, 2017, Lyles signed a minor league agreement with the San Diego Padres.
He was given free agency on November 2, 2017. The Padres signed Lyles to a one-year, $1 million contract to stay with the team on December 17, 2017.
Lyles signed a one-year, $2.05 million contract with the Pittsburgh Pirates for the 2019 season on December 17, 2018. Lyles signed a two-year, $16 million contract with the Texas Rangers on December 13, 2019.
He went 1–6 with a 7.02 ERA in 2020. With 45 earned runs allowed, he is tied for first in the AL. In 180 innings pitched in 2021, Lyles went 10–13 with a 5.15 ERA and 146 strikeouts. With 38 home runs allowed, he led the majors.
On March 12, 2022, Lyles signed a significant one-year, $5.5 million contract with the Baltimore Orioles. Jordan Lyles’s net worth is estimated to be approximately $5 million.