Itzler is a happily married man. He married Sara Blakely in 2008. The wedding was attended by actor Matt Damon and featured a surprise performance by singer Olivia Newton-John. His wife Sara Blakely is the founder of Spanx, an American underwear maker focusing on shaping briefs and leggings, founded in Atlanta, Georgia.
The couple owns and manages the company together. In 2012, Blakely was named in Time magazine’s “Time 100” annual list of the 100 most influential people in the world. In 2014, she was listed as the 93rd most powerful woman in the world by Forbes.