Before fame, Holland started out as a lead vocalist with The Satintones. He produced In the Name of Love, Stop! , How Sweet It Is (To Be Loved by You), Baby Love, and other countless Motown songs. Holland served as the team’s musical arranger and producer, along with Lamont Dozier.
He is best known as a member of Holland-Dozier-Holland, the songwriting and production team that was responsible for much of the Motown sound and numerous hit records by artists such as Martha and the Vandellas, The Supremes, The Four Tops, and The Isley Brothers. In 1988, he was inducted into the American Songwriters Hall of Fame together with Lamont Dozier and Eddie Holland.
He was inducted into the Rock and Roll Hall of Fame together with Lamont Dozier and Eddie Holland in 1990. He founded Hot Wax Records (1968-1973) and Invictus Records (1968-1977) together with Lamont Dozier and Eddie Holland.
Brian Holland, Lamont Dozier, and Eddie Holland were awarded a Star on the Hollywood Walk of Fame for Recording at 7070 Hollywood Boulevard in Hollywood, California.
